ANS Performance CreXcel 30 Serves 08/19
ENERGY - AT THE SOURCE OF IT ALL
Everyone could use more energy. Whether it's to run farther, train longer, or tackle your day - you need more gas in the tank. But relying on countless cups of coffee and energy shots to make it through the day, results in an endless cycle of highs and lows.There's a better way. You can improve the body's ability to generate energy naturally, and tapping into that is the holy grail of performance.
Our bodies ‘make' energy with the foods we consume (carbs, fats, proteins); and converts them to the high-energy compound called ATP (Adenosine triphosphate). ATP is the chemical energy currency that fuels everything we do from our heart beat to bench pressing 315 lbs.
Having more energy means improving the efficiency of ATP production by our cells and having more accessible ATP. Our bodies generate ATP in different ways depending on the type of exercise we do - aerobic vs. anaerobic, but it almost all happens within a tiny cellular organelle called the MITOCHONDRION.
Mitochondria generate most of the energy that our cells need to do their jobs. For muscular contraction, there are 3 modes of ATP generation:Crexel Page 1 (1) from Creatine Phosphate (PCr), (2) from Glycogen (stored glucose), and (3) from the Kreb's Cycle (conversion of macronutrients into energy within the mitochondria).
Creatine phosphate is typically stored in larger amounts in cells than ATP (10x greater) and can be depleted to rapidly resynthesize ATP. Similarly, glycogen can be metabolized to provide quick bursts of ATP. Both of these two sources are engaged during very short duration, high intensity exercise where oxygen delivery is not abundant (anaerobic conditions)
Of the 3 energy sources - ATP generated in the mitochondrion from carbohydrates and fats is much more significant. As the duration of exercise continues, oxygen availability to contracting muscles increases and ATP coming from cellular respiration provides most of the energy for skeletal muscle contraction. Much more ATP is generated from 1 Kreb's cycle of cellular respiration than any anaerobic metabolism:
CELLULAR APT SOURCES DURINING EXERCISE
|1. Creatine-Phosphate (PCr) (Anaerobic)||2. Glycogen/Glucose (Anaerobic)||3. Cellular Respiration (Kerb's Cycle)|
|1 PCr yields 1 APT||1 Glucose yields 2 ATP|
CREATINE & ITS ROLE IN CELLULAR ENERGY
Creatine is a dietary protein-like compound found in meat and fish. Muscle tissue does not produce creatine, and therefore it must take up creatine from the bloodstream. Once inside muscle cells, creatine gets a high-energy phosphate attached to it and is then known as creatine-phosphate (PCr). It is this high-energy molecule that is one of the most critical components of creatine's beneficial effects in the body. That's because PCr donates its high-energy phosphate to create ATP, which is used by the muscle for the rapid energy it needs for muscle contraction, such as during weight-lifting. Having more PCr in muscle cells means more ATP can be rapidly produced during exercise, allowing you to exert yourself more, which can lead to gains in strength, power, speed and muscle growth.
Supplementation with Creatine can saturate creatine stores in muscle cells and therefore enhance creatine-phosphate levels and availability. While there are constantly new forms of creatine coming onto the market, no form of creatine is more tried, tested and true than Creatine Monohydrate.
- Creatine monohydrate is one of the most stable forms of creatine in solution
- 99% of creatine monohydrate is either absorbed by muscle tissue or excreted through sweat or urine
- Creatine monohydrate is not degraded to creatinine during normal digestion
Several creatine manufacturing companies market that their forms of creatine may be more absorbable because in water they are more soluble - but typically this is just an artifact of pH manipulation of the solution (either acidic like with Creatine HCl or basic as with Creatine buffered with bicarbonate). At the end of the day, you can't actually absorb much more than 99% can you? Here is a table comparing the potency of different forms of creatine based on a gram vs. gram comparison, and some of the marketed claims of each. Which would you choose?
TYPE OF CREATINE
|Creatine Monohydrate||Creatine Hydrochloride (HCL)||Creatine bicarbonate
|% Creatine content
(per gram material)
|# of human cinical Studies||200+||1||1||0|
|Marketed Benefits||Increase Power, Strength & Muscle Recovery||More soluble than creatine mono (Micro dosing?)||Buffered creatine stable against creatinine degradation||Higher solubility & added value of nitrate|
|The Reality||1. Gram for gram Creatine Monohydrate delivers significantly more creatine than other forms.|
|2. Creatine is creatine, the 'salt' version does not play an active ergogenic role in enchancing the creatine benefits.|
|3. Solubility of creatine in water does not necessarily improve bioavailability - but may aid in gastric distress. Creatine Monohydrate ios already nearly 100% bioavailable - so any improvement is neglible.|
|4. About 5 grams of creatine daily is typically required to maintain cellular saturation, based on creatine potency this actaully wquates to 5.64g of Creatine HCL, 20g of KreAlkalyn and 6.5g of Creatine Nitrate.|
MITOCHONDRIA & CELLULAR ENERGY
Aerobic cellular energy production happens within the walls of the mitochondria. These cellular powerhouses churn out the majority of the body's energy incredibly efficiently (i.e. a net of approximately 30 ATP molecules per 1 sugar (glucose) molecule). The Krebs' Cycle is a critical component in producing large amounts of cellular energy. It is the main energy producer at rest and for low-moderate intensity exercise and for longer durations of aerobic and even anaerobic exercise. There are numerous substrates, co-factors, minerals, enzymes and steps involved in making it all work. Just take a look at the Kreb's Cycle, the engine behind each cycle of ATP creation.
There are several Kreb's Cycle Intermediates including citrate, malate, fumarate, alpha-ketoglutarate (AKG) and succinate which have supporting literature in their roles in energy recovery and performance. These key ingredients make up the exclusive KrebsPower™ mineral substrate complex - only found in CreXcel.
CREXCEL™ IS THE FIRST CREATINE SUPPLEMENT TO ENTER THE MARKET THAT TARGETS MORE THAN ONE ROUTE OF CELLULAR ENERGY OPTIMIZATION.
CREXCEL WILL MAXIMIZE AVAILABLE ENERGY STORAGE AND ATHLETIC PERFORMANCE SEVERAL WAYS:
- Saturates cellular creatine levels for optimalphospho-creatine ATP generation
- Fuels the Citric Acid Cycle with novel KrebsPower™ mineral cofactor substrate complex
- Supports mitochondrial efficiency with Water-Soluble CoenzymeQ10 (CoQ10) complex
- Boosts cellular CoQ10 levels over 100% with Q-Xcel™ Shilajit extract
- Increases muscular endurance and performance capacity with R2•Rev™
- Elevates muscle power, strength & recovery
A CLOSER LOOK
At its core CreXcel delivers 5 grams of creatine monohydrate per serving - the most studied, efficacious and safest form of creatine available. For anerobic performance like weight training, it's critical to have ample Creatine-Phosphate (PCr) stores to quickly replenish depleted ATP, which can happen within seconds. While other products typically stop there or offer up a new unproven form of creatine - this is where CreXcel is just getting warmed up.
It is just as important to have a well-oiled aerobic ATP generation system in place to quickly remove lactic acid, and provide the bulk of cellular energy for exercise. CreXcel doesn't neglect this import piece of the puzzle and supplies important enzyme co-factors like Magnesium, Calcium and Niacin to optimize Kreb's Cycle efficiency. These minerals are bound to a unique KrebsPower™ substrate system consisting of succinate, malate, fumarate, citrate and alpha-ketoglutarate - all of which arekey enzymatic substrates in the generation of ATP in the mitochondria.
Taking the science to the next level, CreXcel also includes a potent combination of a highly bioavailable water soluble CoQ10 complex with Q-Xcel™ Shilajit extract. Strenuous exercise can induce ATP declines in muscle, blood and brain tissue. Supplementing with a combination of Shilajit extract and CoQ10 can prevent natural ATP decline and doubles to increase cellular CoQ10 levels more than 100% higher than with supplementation of either ingredient alone. CoQ10 plays an essential role in the electron transport chain within the mitochondria, ensuring efficient transfer of electrons forATP production; in fact 95% of all cellular energy production depends on it.
Not done yet though. CreXcel also includes the potent R2•Rev™ Rhodiola rosea extract. This adaptogenic herb supports human performance and endurance by activating the synthesis or re-synthesis of ATP and stimulating energy-repair processes after intense exercise.Together this combination of ingredients take a holistic approach to optimizing cellular energy production and availability for human performance.